Abstract: AIM: To investigate the influence of aspirin on the efficacy of captopril in the treatment of chronic congestive heart failure (CHF). METHODS: 74 cases of CHF were divided into 2 groups depending on whether aspirin was administrated before captopril was given, then all patients were given captopril 12.5 - 25 mg, tid, for 28 days. RESULTS: In aspirin group, marked effective rate was 46.7 %, and total effective rate was 70 %, superior to that in no aspirin group (P < 0.05).The heart rate (HR) evidently decreased (P < 0.05) in aspirin group.Other indices, including the left ventricular ejection fraction (LVEF), fraction shortening (FS) and the rate of filling velocity in early diastole over that in late diastole (E/A), were significantly increased (P <0.01) in aspirin group. CONCLUSION: The longer is the administration of aspirin, the poorer is the effects of captopril added in the treatment of CHF.

Key words: aspirin, captopril, chronic congestive heart failure