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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2002, Vol. 7 ›› Issue (6): 496-499.

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Meta-analysis of the effectiveness of defrase and other drugs in treatment of acute cerebral infarction

JIANG Ya-Bin, ZHU Ning   

  1. Department of Emergency,First Affiliated Hospital of JNUMC,Guangzhou 510632
  • Received:2002-07-22 Revised:2002-08-03 Online:2002-12-26 Published:2020-11-20

Abstract: AIM: To explore the difference of efficacy between defibrase and other drugs in treatment of acute cerebral infarction.METHODS: The efficacies of defibrase or other drugs in treatment of acute cerebral infarction were analyzed by Meta-analysis in homogeneity test and combined test in 10 studies.RESULTS: (1)Homogeneity test showed that the cited studies were homogeneous with χ2=6.8452,p>0.05;and(2)in combined test,the combined OR=3.2353 and its 95% confidence interval was in 2.21 -4.74(χ2=36.2,p<0.001).CONCLUSION: The effectiveness of defibrase in treatment of acute cerebral infarction is significantly superior to those of the medications used at present.It is necessary to further investigate the relationships between its clinical efficacy and the dosages,and between protocols of drug administration and indications.

Key words: acute cerebral infarction, defibrase, Meta-analysis

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