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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2002, Vol. 7 ›› Issue (6): 508-510.

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Effects of propofol against myocardial MDA metabolism and water content after ischemia/reperfusion injury in isolated rat hearts

JIA Dong-Lin, ZHAO Hong, WANG Xu-Dong1   

  1. Department of Anesthesiology of the 3rd Affiliated Hospital;
    1Department of Heart surgery of the 2nd Affiliated Hospital,China Medical University,Shenyang 110022
  • Received:2002-05-30 Revised:2002-07-15 Online:2002-12-26 Published:2020-11-20

Abstract: AIM: To investigate the effect of propofol on myocardial malondialdehyde(MDA)metabolism and water content after ischemia/reperfusion injury in isolated rat heart with the modified Langredorff model.METHODS: Twenty four rats were randomly divided into four groups.Rat hearts were perfused with Krebs-Henseleik(K-H)in normal control group.In other three groups,a three-phase protocal was performed:(1)15 -30 min preperfusion,(2)20 min global normothermic(37℃)ischemia,and(3)30 min reperfusion.Then the grouppwas treated with 30 μmol·L-1propofol,the groupp+G 30 μmol·L-1 propofol+10 μmol·L-1 glibenclamide before ischemia and throughout the experiment.Only K-H buffer was perfused in the groupI-R.The content of water and MDA in myocardium and creatin kinase(CK)in the coronary effluent were measured.RESULTS: The recovery of hearts treated with propofol were better than that of groupI-R,indicated by lower content of water,MDA and CK level(p<0.01).No statistically significant differences were observed between grouppand groupp+G(p>0.05).CONCLUSION: Propofol can relieve myocardial edema by scavenging oxygen free radical and the mechanism is related to open of KATpchannels.

Key words: propofol, myocardial edema, myocardial, reperfusion injury

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