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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2002, Vol. 7 ›› Issue (6): 574-576.

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Recent advances in genetic therapy for anti-hepatitis B virus

YU Yong-Sheng, CHEN You-Hua   

  1. Shanghai Sixth People' s Hospital,Shanghai 200233;
    1Department of Infectious Diseases,Affliated Yijishan Hospital,Wannan Medcal College,Wuhu 241001
  • Received:2001-07-25 Revised:2001-08-08 Online:2002-12-26 Published:2020-11-20

Abstract: With the development of molecular biology,especially gene engineering technique,genetic therapy for anti-hepatitis B virus was deeply researched.Employing techniques of gene recombinant,transgene,and anti-sense nucleic acid etc,the function of genetic therapy for anti-hepatitis B virus was verified in cellular level or through animal experiment.In this article,studies on gene trangenically IFN,DNA vaccine(DNA immunization),antisense oligodeoxynucleotide(ONas),triple helix forming oligodeoxynucleotide(TFO),anti-gene oligodeoxynucleotide(ONan),ribozyme were reviewed.

Key words: heptitis B, gene trangenically IFN, DNA vaccine, antisense oligodeoxynucleotide(ONas), triple helix forming oligodeoxynucleotide(TFO), ribozyme

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