Abstract: AIM: To study the enhancing effect of penetration enhancer on percutaneous absorption of antifungal agents.METHODS: Percutaneous penetration experiment was performed on device in vitro, and the deposit effects were observed with vivoperception.RESULTS: Combination of 1-menthol (1 %) and azone (1 %) showed the best effect on percutaneous absorption of cidopicox olamine, and 1-menthol (1 %) had the best effect on percutaneous absorption of salysic acid.The compound penetration enhancer, consisting of 1-menthol (1 %), azone (1 %), propylene glycol (2.5 %) and oleic acid (2.5 %), had prominent action on absorption of cidopirox olamine through rabbit skins, and shorten the lag times obviously.CONCLUSION: L-menthol and azone can significantly enhance the percutaneous absorption of both salysic acid and cidopicox olamine.Combination of 1-menthol and azone can further increase the absorption.

Key words: pharmacology, salysic acid, ciclopirox olamine, percutaneous absorption, deposit effect