Abstract: AIM: To compare the efficacy and safety between cefepime and ceftazidme in the treatment of the moderate to severe low-respiratory tract infection. METHODS: Sixty patients with moderate to severe lowrespiratory were enrolled in two groups.30 patents were treated with ceftzidem and other patients were given cefepine as a control.The dosage of both drugs was 1 -2 g (1 g for moderate infection, 2g for severe infection). The duration of treatment was 7 -10 d for most patients in the two groups. RESULTS: The efficacy rates of cefepime and ceftazidme were 96.67 %and 86.67 %, respectively, whereas the bacterial efficacy rates were 92.28 % and 88.0 %(P >0.05).The adverse reactions in two groups were mild and the incidence were not statistical difference between two groups (P >0.05). CONCLUSION: Cefepime is a safe and effective agent in treatment of low-respiratory tract infection like ceftazidme.

Key words: cefepime, ceftazidme, efficacy, safety