Relation between activation of hippocampal astrocytes and ischemic tolerance induced by 3-nitropropionic acid in gerbils1

Abstract

Abstract: AIM: To investigate the relationship between astroglial activation state and ischemic tolerance induced by low dose of 3-nitropropionic acid (3-NPA) in gerbil hippocampus. METHODS: Transient forebrain ischemic model was induced by bilateral common carotid arteries occlution.HE staining and immunohistochemistry were used to identify neuronal and astrocyte response. RESULTS: Preconditioning with 3-NPA produced protective effects of CA1neurons.The number of glial fibrillary acidic protein positive astrocyte in hippocampal CA₁ region increased slightly in control group, but increased significantly in preconditioning of the brain with 3-nitropropionic acid. CONCLUSION: The state of astroglial activation is related to neuronal survival in ischemic tolerance induced by low dose of 3-nitropropionic acid.

Key words: pharmacodynamics, 3-nitropropionic acid, cerebral ischemic tolerance, astrocyte, hippocampus, gerbil

CLC Number:

R971
R965

ZHU Hong-Can, SUN Sheng-Gang, LI Hong-Ge. Relation between activation of hippocampal astrocytes and ischemic tolerance induced by 3-nitropropionic acid in gerbils¹[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2003, 8(2): 139-142.

References

[1] Riepe MW, Esclaire F, Kasischke K, et al.Increased hypoxic tolerance by chemical inhibition of oxidative phosphorylation: chemical preconditioning[J].J Cereb Blood Flow Metab, 1997; 17:257-264
[2] Brambrink AM, Noppens R, Dick WF.3-nitropropionic acid induces tolerance against global brain ischemia in rats[J].Soc Neurosci Abstr, 1998;24:253
[3] Wiegand F, Liao W, Busch C, et al.Respiratory chain inhibition induces tolerance tofocal cerebral ischemia[J].J Cereb Blood Flow Metab, 1999;1229-37
[4] Fontaine MA, Geddes JW, Banks A, et al.Effect of exogenous and endogenous antioxidants on 3-nitropionic acid-induced in vivo oxidative stress and striatal lesions:insights into Huntington's disease[J].J Neurochem, 2000;75:1709-15
[5] Vis JC, VerbeekMM, Waal RM, et al.The mitochondrial toxin 3-nitropropionic acid induces differential expression patterns of apoptosis-related markers in rat striatum[J].Neuropathol Appl Neurobiol, 2001;27:68-76
[6] Sugino T, Nozaki K, Takagi Y, et al.3-Nitropropionic acid induces ischemic tolerance in gerbil hippocampus in vivo[J]. Neurosci Lett, 1999;259:9 -12 7 Rejdak R, Rejdak K, Sieklucka M, et al.Brain Tolerance and preconditioning[J].Pol J Pharmacol, 2001;53:73-9
[7] Brambrink AM, Schneider A, Noga H.Tolerance-Inducing dose of 3-nitropropionic acid modulates bcl-2 and bax balance in the rat brain:a potential mechanism of chemical preconditioning [J].J Cereb Blood Flow Metab, 2000;20:1425-36
[8] Riepe MW, Niemi WN, Megow D, et al.Mitochondrial oxidation in rat hippocampus can be pre conditioned by selective chemical inhibition of succinic dehydrogenase [J].Exp Neurol, 1996;138:15-21
[9] 敬军, 陈青.脑缺血再灌流后海马区细胞凋亡的研究[J]. 中国临床神经科学, 1999;7:38-40
[10] Stoll G, Jander S, Schroeter M, et al.Inflammation and glial responses in ischemic braion lesions [J].Prog Neurobiol, 1998;56:149-71

[1]	WU Yujie, ZHAO Chengcheng, XI Qing. Evaluation of tegacycline regimens in treatment of gram-negative bacterial infections with Monte Carlo simulation [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(9): 1027-1033.
[2]	GU Yifei, CHU Nannan, HUANG Kai, QUE Linling, ZHANG Jisheng, XIANG Xuemei, HE Qing. Application and progress of pharmacodynamics study in bioequivalence evaluation of orally inhaled drug products [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(7): 822-833.
[3]	ZHANG Jing, GAO Danyang, YU Kang, LIN Xiaowan, CAO Ying, LIU Xiao, MIAO Huihui, LI Tianzuo. Effects of different inhalation anesthetics on glial cells activation in neonatal rats [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(12): 1391-1399.
[4]	ZHANG Jinhua, LIU Maobai, CAI Mingzhi, ZHENG Yingli, LAO Haiyan, XIANG Qian, DU Liping, ZHU Zhu, DONG Jing, ZUO Xiaocong, LI Xingang, SHANG Dewei, CHEN Bing, YE Yanrong, WANG Yuzhu, GAO Jianjun, ZHANG Jian, CHEN Wansheng, XIE Haitang, JIAO Zheng. Model informed precision dosing of warfarin: China expert consensus report (2022 version) [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(11): 1201-1212.
[5]	XU Liying, ZHANG Gaosong, HUANG Xiaomin, HUANG Jihan, WANG Shuhua. Clinical efficacy and modeling evaluation of He-wei-zhi-xie capsules in treating diarrhea patients [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(1): 47-55.
[6]	JIAO Zheng, LI Xingang, SHANG Dewei, DONG Jing, ZUO Xiaocong, CHEN Bing, LIU Jianmin, PAN Yan, ZHOU Tianyan, ZHANG Jing, LIU Dongyang, LI Lujin, FANG Yi, MA Guangli, DING Junjie, ZHAO Wei, CHEN Rui, XIANG Xiaoqiang, WANG Yuzhu, GAO Jianjun, XIE Haitang, HU Pei, ZHENG Qingshan. Model informed precision dosing: China expert consensus report [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(11): 1215-1228.
[7]	LI Wenchao, BAI Xiangrong, LI Xiaoling, JIANG Dechun. Population pharmacokinetics/pharmacodynamics of tigecycline in the treatment of different infectious diseases [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(11): 1265-1272.
[8]	XIANG Rongfeng, SUN Fengjun, XIONG Lirong, YU Mingjie, DAI Qing, CHEN Yongchuan. Pharmacokinetics and pharmacodynamics of (S)-pantoprazole sodium enteric-coated tablets in healthy subjects [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(8): 903-909.
[9]	LI Jian, YANG Jinbo, WANG Yuzhu. Applications of model-informed drug development (MIDD) on new drug research and development [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(1): 1-8.
[10]	YUAN Li, HAN Lingna, CHANG Yongli, ZHANG Cuiying. Study on GIP analogues against the cognitive impairments in APP/PS1 transgenic mice [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(7): 721-729.
[11]	DU Tianping, MENG Zudong. Mechanism of 17β-estradiol on p38MAPK signal transduction pathway in propofol-induced hippocampal neuronal apoptosis in developing rats [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(2): 128-133.
[12]	MA Guangli, XU Ling, CHEN Rui, CHEN Yuancheng, ZHAO Wei, LIU Dongyang, JIAO Zheng, LI Jian, JI Shuangmin, LI Li, LI Liang, WANG Yuzhu, YANG Jinbo, WANG Yaning, SUN He, HU Pei, ZHENG Qingshan, LU Wei. General considerations of population pharmacokinetic/pharmacodynamic study in new drug development [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(11): 1201-1220.
[13]	LIAN Yanhong, JIANG Huifang, YUAN Xiaohong, ZHOU Huidan, XIE Kangjie, FANG Jun, JIN Xiaoju. Effects of neoadjuvant chemotherapy on the pharmacodynamics of rocuronium bromide in patients undergoing gastric cancer surgery [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(10): 1161-1164.
[14]	ZHANG Chao . Pharmacodynamic studies evaluation of voriconazole [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(1): 116-120.
[15]	WEI Huiming, MA Weiqing, LI Wenfeng, WANG Huiming. Effect of antagonist of NR2A-containing N-methyl-D-aspartate receptors on synaptic long-term potentiation in hippocampus in rats with neuropathic pain [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(9): 1008-1011.

Relation between activation of hippocampal astrocytes and ischemic tolerance induced by 3-nitropropionic acid in gerbils¹

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments