Abstract: AIM: To evaluate the effect of mizolastine in patients with chronic urticaria and to explore the role of IL-4 in the process of chronic urticaria. METHODS: 32 cases of chronic urticaria were treated with mizolastine, and the therapeutic effects and the side-effect were evaluated.The serum IL-4 levels were tested by ELISA. RESULTS: The total effective rates were 62.5 % and 84.4 % (P <0.05) at the end of 1 wk and 2 wk, respectively.The side-effects were found in 3 cases (9.4 %).The average levels of serum IL-4 before treatment were higher than those in controls (P <0.01), but after treatment were not (P >0.05), and before treatment were significantly higher than those after treatment (P <0.01). CONCLUSIONs: Mizolastine is an effective and safe drug in the treatment of patients with chronic urticaria and the serum level of IL-4 decreases.

Key words: pharmacodynamics, mizolastine, chronic urticaria, evaluation, IL-4