1 Takahshi M,Billups B,Rossi D,et al.The role of glutamate transporters in glutamate homeostasis in the brain[J].J ExPBiol,1997;200:401-9
2 Jabauon D,Scanziani M,Gahwiler BH,et al.Acute decrease in net glutamate uptake during energy deprivation[J].Proc Natl Acad Sci UAS,2000;97:5610-5
3Pillis JW,Ren J,O' Regan MH.Transporter reversal as a mechanism of glutamate release from the ischemic rat cerebral cortex:studies with DL-threo-beta-benzyloxyaspartate[J].Brain Res,2000;868:105-12
4 Seki Y,FeustelPJ,Keller RW Jr,et al.Inhibition of ischemia-induced glutamate release in rat striatum by dihydrokinate and an anion channel blocker[J].Stroke,1999;30:433-40
5 Douen AG,Akiyama K,HoganMJ,et al.Preconditioning with cortical spreading depression decreases intraischemic cerebrallutamatelevels and down-regulates excitatory amino acid transporters EAAT1 and EAAT2 from rat cerebral cortexPlasma membranes[J].J Neurochem,2000;75:812-8
6 Griffith OW.Biologic andPharmacologic regulation of maintain glutathione synthesis[J].Free Radic boilMed,1999;27:922-35
7Piani D,Fontana A.Involvement of the cy stine transport system Xc-in macrophage-induced glutamate-dependent cytotoxicity to neurons[J].J Immunol,1994;152:3578-85
8 Shanker G,Aschner M.Identification and characterization of uptake systems for cystine and cysteine in culture astrocytes and neurons:Evidence for methylmercury-targeted disruption of astrocyte transport[J].J Neurosci Res,2001;166:998-1002
9 McBean GY,Flynn J.Molecular mechanisms of cystine transport[J].Biochem Soc Trans,2001;29:717-22
10 Schubert D,Piaseki D.Oxidative glutamate toxicity can be a component of the excitotoxicity cascade[J].J Neurosci,2001;21:7455-62
11 Trotti D,Danbolt NC,Voltena A.Glutamate transporters are oxidant-vulnerable:a molecularlink between oxidative and exictoxic neurodegeneration[J] ?TrendsPharmacol Sci,1998;19:328-34
12 Ratan RR,Baraban JM.Apoptotic death in vitro model of neuronal oxidative sress[J].Clin ExpPhamarcolPhysiol,1995;42:309-10
13 Cho ES,Johnson N,Suider BC.Tissue glutathione as reservoir during cyst(e)ine depletion in growing rats[J].J Nutr,1984;114:1853-62
14 MartinM,MaciasM,Escames G,et al.Melatonin but not vitC and E maintains glutathione homeostasis in t-butyl hydroperoxide-induced mitochondrial or oxidative stress[J].J FASEB,2000;14:1677-9
15 Han D,Sen CK,Roy S,et al.Protection against glutamateinduced cytotoxicity in C6 glial cells by thiol antioxidants[J].Am JPhy siol,1997;273:R1771-8
16 Tan S,Sagara Y,Liu Y,et al.The regulation of reactive oxygen speciesProduction duringProgrammed cell dath[J].J Cell Biol,1998;141:1423-32
17Perez Velazquez JL,Frantseva MV,CarlenPL.In vitro ischemiaPromotes glutamate-induced free radical generation and intracellular calcium accumulation in hippocampalPyramidal neurons[J].J Neurosci,1997;17:9085-94
18 Schinder AF,Olson EC,Spitzer NC,et al.Mitochondrial dysfunction is aPrimary event in glutamate neurotoxicty [J].J Neurosci,1996;16:6125-33
19 Hunter DR,Haworh RA,Southard JH.RelationshiPbetween configuration,function andPermeability in calcium-treated mitochondria[J].J Biol Chem,1976;251:5069-77
20 Yoshimura S,Banno Y,Takenaka K,et al.Ceramide formationleads to caspase-3 activation during hypoxicPC12 cell death:inhibitory effects of bcl-2 on ceramide formation and caspase-3 activation[J].J Biol Chem,1998;273:6921-7
21 Yoshimura S,Banno Y,Nakashima S,et al.Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxicPC12 cell death [J].J Neurochem,1999;73:675-83
22 Zhivotovsky B,Orrenius S,Brastugun OT,et al.Injected cytochrome c induces apoptosis[J].Nature,1998;391:449-50
23 Yang J,Liu X,Bhalla K,et al.Prevention of apoptosis by bcl-2:release of cytochrome c from mitochondria blocked[J].Science,1997;275:1129-32
24 Kluck RM,Bossy-Wetzel E,Green DR,et al.The release of cytochrome c from mitochondria:APrimary site for bcl-2 regulation of apoptosis[J].Science,1997;275:1132-6
25 Kirkland RA,Franklin JL.Evidence for redox regulation of cytochrome c release duringProgrammed neuronal death:Antioxidant effects ofProtein synthesis and caspase inhibition[J].J Neurosci,2001;21:1949-63
26 ZhangP,Liu B,Kang SW,et al.ThioredoxinPeroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of bcl-2[J].J Biol Chem,1997;272:30615-8
27 Baek SH,Kim JY,Choi JH,et al.Reduced glutathione oxidation ratio and 8ohG accumulation by mild ischemicPretreatment[J].Brain Res,2000;856:28-36
28 Schulz JB,Weller M,Moskowtz MA.Caspases as treatment targets in stroke and neurodegenerative diseases[J].Ann Neurol,1999;45:421-9
29 Hirashima Y,Kurimoto M,Nosami K,et al.Correlation of glutamate-induced apoptosis with caspase activaties in cultural cortical neurons[J].Brain Res,1999;849:109-18 |
