Abstract: AIM: To evaluate the therapeutic effect and safety of the rifamycin sodium injection (SV)in treatment ofPatients withPulmonary tuberculosis.METHODS: 44 cases ofPulmonary tuberculosis were randomly allocated to two groups:rifamycin sodium grouPand routine treatment group.Chemotherapy regimens:in the rifamycin sodium group,21 cases were treated with the regimen of 2HZE +SV/7HR;and in the routine treat-ment group,23 cases were treated with the regimen of 2HRZE/7HR.RESULTS: The sputum negative conver-sion rate of the rifamycin sodium grouPwas 85.7%,and the foci vanishing rate was 90.5%,while the both rates in the routine treatment grouPwere 60.9%and 60.9%,respectively.There was significant difference between the two groups (P<0.05).CONCLUSION: The therapeu-tic regimen with SV is effective in the sputum negative conversion and vanishing of foci.

Key words: pharmacodynamics, rifamycin sodium injection, rifampin, pulmonary tuberculosis