Abstract: AIM: To observe the efficacy and safety of topotecan on hard-cured small celllung cancer(SCLC).METHODS: 38Patients of hard-cured SCLC were treated with topotecan 1.2 mg·m^-2·d^-1(iv)on d_{1~ 5}and 21 days a cycle and the treatmentlasted for 2-3 cycles.RESULTS: The response rate to topotecan was 23.68% (9/38)including 36.36% (4/11)inlimited type and 18.52%(5/27)in extensive type.There were no statistical differences between them (χ²=0.567,P>0.05).The main side reactions were neutropenia and thrombocytopenia with incidence of 23.68% and 26.32%in gradeⅢ+Ⅳ,respectively,but without side reaction to hemoglobin.CONCLUSION: Topotecan is an effective agent in the treatment ofPatients with SCLC.

Key words: pharmacodynamoics, topotecan, small celllung cancer, hard-cured, chemotherapy