Abstract: AIM: To evaluation the efficacy dosages of topiramate(TMP)in treatment ofPatients with different types of epilepsy.METHODS: The seizure rate in baselinePhase ofPatients with epilepsy were observed and recorded before treatment of topiramate as monotherapy for 20 weeks.The TMPstarting dosage was 25 mg·d^-1,and then increased to 25 mg·d^-1each week for 8 weeks until effective dosage or 200 mg·d^-1for 12 weeks,and the change of seizure frequency and adverse reactions were recorded.RESULTS: The seizure in 31 cases(51.7%)was totally controlled,seizure reduction of≥75%was in 14 cases(23.3%),≥50%was in 4 cases(6.7%),and<50% was in 11 cases(18.3%).ThePatients with shorter duration andlowered seizure rate showed better effect,and TMPwas extremely effective at controlling a variety of seizures without causing excessive seizure aggravation.There was no severe bad reaction during the course of treatment.CONCLUSION: TMPas monotherapy is effective to different types of epilepsy,and it is also well-tolerated and safety.But the dosage of TMPshould be adjusted for eachPatient,and generally the maximum dosage should not be over 100 mg·d^-1.

Key words: pharmacodynamics, topiramate, epilepsy, monotherapy, efficacy evaluation