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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2004, Vol. 9 ›› Issue (1): 59-62.

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Antitumor effect of hydrochloride 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3, 3-diphenyl-propyl ester

GUO Wei, RAN Fu-Xiang, WANG Rui-Qing, CUI Jing-Rong, LI Run-Tao1, CHENG Tie-Ming1, GE Ze-Mei1   

  1. National Research Laboratory of Natural and Biomimetic Drugs, Beijing 100083, China;
    1Department of Chemical Biologz School of Pharmaceutic Sciences, Beijing Univiersity, Beijing 100083, China
  • Received:2003-07-02 Revised:2003-07-18 Online:2004-01-26 Published:2020-11-16

Abstract: AIM: To study the inhibition effects of the hydrochloride 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3, 3-diphenyl-propyl ester (Hyd) on the growth of transplant carcinoma in mice.METHODS: The growth of tumor was observed by models of transplant tumor in mice.RESULTS: The inhibition rates of Hyd against tumor growth of S180 and H22 implanted human gastric carcinoma were 46.4 %-59.6 %, 39.3 %-51.6 % and 18.1 %-59.0 %, respectively in nude mice.CONCLUSION: Hyd can inhibit the growth of transplanted hepatocyte carcinoma 22, sarcoma 180 in mice, and implanted human gastric carcinoma in mice and nude mice.

Key words: hydrochloride 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3, 3-diphenyl-propyl ester, sarcoma 180, hepatocyte carcinoma 22, implanted human gastric carcinoma

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