Abstract: AIM: To study the effects of the composite lactogenic decoction (CLD) on milk secretion of hypoprolactinemia induced by L-dopa in rats.METHODS: The models of hypoprolactinemia were established with Ldopa in rats. The weight of young rats was recorded during 15 days. Levels of serum prolactin were detected by ELISA and the mammary gland histology was observed by electron microscop.RESULTS: The administration of CLD (3, 6 and 20 g ·kg^-1) by the way of ig increased serum prolactin (PRL) level significantly (P<0.05 or 0.01) induced by L-dopa in rats at a dose-dependent manner.CLD increased the weight of young rats (P<0.05) and promoted the mammary grand growth of rats.CONCLUSION: CLD can reverse the symptom of hypoprolactinemia induced by L-dopa and promote the secretion of milk in rats.

Key words: composite lactogenic decoction, L-dopa, hypoprolactinemia, prolactin