Abstract: AIM: To study the effects of different dose of domestic recombinated human granulocyte colony stimulating factor (rhG-CSF) on leucopenia induced by chemotherapy in patients with gynecological tumors. METHODS: 98 patients with gynecological tumors (ovarian cancer 36, endometrial carcinoma 28,cervical cancer 34) were randomly divided into 3 groups. RhG-CSF (domestic) was given at the dose of 75 μg·d^-1, S. C in group A, rhG-CSF (domestic) was given at the dose of 150 μg·d^-1, S. C in group B, and rhG-CSF (import) was given at the dose of 75 μg·d^-1, S. C in group C. RESULTS: The amount of WBC and ANC were in-creased by different dose of domestic rhG-CSF and the im-port rhG-CSF. In first cliemoiherapy, the time when the level of WBC raised higher than 4.0×10⁹ L^-1 were no significant difference among 3 groups (P>0.05). But in repeated chemotherapy, the period of leukopenia recov-ered to normal was shorter in group B than that in group A or group C. The effects of the domestic rhG-CSF on leu-copenia induced by chemotherapy were similar to the im-ported products of same dose. CONCLUSION: Low dose of domestic rhG-CSF (75 μg) can effectively treat the leukopenia caused by postchemotlierapy in patients with gynecological tumors. 150 μg of domestic rhG-CSF is more effective than 75 μg of domestic or import rhG-CSF in treating leukopenia in repeated chemotherapy.

Key words: chemotherapy, recombinated human granulocyte colony stimulating factor (rhG-CSF), ovarian cancer, endometrial carcinoma, cervical carcinoma