Abstract: AIM: To study the analgesia and anti-inflammation effects of aspirin-niacinamide-zinc complex (WUY).METHODS: In this study, the mice ear swelling, vascular permeability increasing and rats'paw edema were adopted to evaluate the anti-inflammable effects of WUY.And the analgesic effects of WUY were tested by writhing reaction and hot-plate method.RESULTS: In high and low dose groups of WUY, the degrees of ear swelling were 3.3 and 2.8 mg·kg^-1) prolonged incubation period of hot-plate reaction and showed marked inhibition effects on writhing induced by acetic acid in mice.CONCLUSION: The analgesic and antiinflammable effects of WUY are stronger than that of ASP.

Key words: aspirin-niacinamide-zinc complex, aspirin, analgesia, anti-inflammation