Relationship of structure and bacteriostasis of 2-(carboxymethoxyl) benzaldehyde benzoyl hydrazone or their complexes

Abstract

Abstract: AIM: To study bacteriostasis activities of ligand (2-(carboxymethoxyl) benzaldehyde benzoyl hydrazone (H2L)) and their complexes.METHODS: Ligand H2L and their complexes were synthesized.The bacteriostasis activities of H2L and their complexes in vitro were tested with K-B method.RESULTS: 2-(carboxymethoxyl) benzaldehyde benzoyl hydrazone only showed bacteriostasis activities on Staphyloccus aureus and their complexes had dramatic bacteriostasis activity on Staphylococcus aureus, Escherichia coli, and Bacillus subtilis.Bacteriostasis ring diameter of Cu-complex was largest.CONCLUSION: Ligand H2L complexes have bacteriostasis activities in vitro.Bacteriostasis activities of Cu-complex are strongest among the complexes.

Key words: hydrazones compounds, ligand, complexes, bacteriostasis, Kirby-Bauer method

CLC Number:

R965
R37

MA Xing-Ming, LUO Yan-Ping, MA Bao-Cheng, YANG Ru-Dong. Relationship of structure and bacteriostasis of 2-(carboxymethoxyl) benzaldehyde benzoyl hydrazone or their complexes[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(2): 201-203.

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Relationship of structure and bacteriostasis of 2-(carboxymethoxyl) benzaldehyde benzoyl hydrazone or their complexes

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