Abstract: AIM: To investigate the effects of ligustrazine (LT)on renal damage of acute ischemia-reperfusion in mice.METHODS: The model of renal ischemiareperfusion in mice was established by clamping the right renal pedicel in situ for 30min before reperfusion of blood 15 min, 60 min, and 24 h.Treated the mice with LT100 mg·kg^-1 ip (ligustrazine group)and saline ip (control group)30 min before operation.The levels of serum creatinine (Scr), blood urea nitrogen (Bun), content of malondialdehyde (MDA)and the activity of superoxide dismutase (SOD)in serum and renal tissue, numbers of WBC adhesion in renal tissue and scores of tubules were detected.RESULTS: LT lowered significantly MDA content and scores of tubules, the number of WBC adhesion, the levels of Scr, BUN, and increased the activity of SOD in renal tissues and serum.CONCLUSION: Ligustrazine may protect the renal damage of acute ischemiareperfusion, and the mechanism is to antagonize the free radical injury and to inhibit WBC adhesion.

Key words: ligustrazine, renal ischemia-reperfusion, anti-oxidation, WBC adhesion