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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2004, Vol. 9 ›› Issue (3): 241-244.

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Progress of caspase inhibitors in pharmacology

ZHANG Hong-Tao, YUAN Shou-Jun, LI Zheng-Qiang   

  1. Department of Pharmacology, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
  • Received:2003-09-08 Revised:2003-10-12 Online:2004-03-26 Published:2020-11-21

Abstract: Apoptosis is involved in a variety of diseases.Cysteine aspartate-specific protease (caspase), a protease family which executes apoptosis, plays a crucial role in course of apoptosis.It can be activated through various pathways.Some natural and synthetic caspase inhibitors will strengthen anti-apoptotic action through inhibiting one or several caspase activity, and will become effective means in treating diseases caused by overapoptosis.

Key words: apoptosis, caspase, inhibitor, cytoprotection

CLC Number: