Abstract: AIM: To observe the effects of puerarin on leaning and memorizing in mice induced by β-amyloid peptide. METHODS: β-amyloid peptide (25-35, 3 μl, 1.0mmol·L^-1) icv to mice was used as an AD animal model.Learning and memorizing ability inmice were inspected through Morris water maze test.In the meantime, the content of SOD and MDA in the mice of cerebral tissue and blood were also inspected. RESULTS: Puerarin 25 and 50mg·kg^-1 improved learning andmemorizing ability in model mice (P <0.05 or P <0.01). And puerarin increased the content of SOD and reduce the content of MDA in cerebral tissue and blood of model mice. CONCLUSION: Puerarin can resist nerve poison of β-amyloid peptide, and the mechanism may be relevant to purge brain free radicals and to increase the activities of antioxidase.

Key words: puerarin, β-amyloid peptide, leaning and memorizing, brain free radical