Effects of Salvia miltiorrhiza Bge on left ventricular hypertrophy in spontaneously hypertensive rats and expression of c-fos

Abstract

Abstract: AIM: To observe the effects of Salvia miltiorrhiza Bge (SMB) on left ventricular hypertrophy (LVH) in spontaneously hypertensive rats (SHR) and the expression of c-fos.METHODS: 18 SHRs in 8 weeks old were divided into three groups at random.SMB or distilled water(1 g·kg^-1 ·d^-1) was injected intraperitoneally to two groups for 10 weeks.Systolic blood pressure(SBP) and left ventricular mass index(LVMI) were measured.HE, VG and immunohistochemical staining combined with computed morphometry were used to evaluated the cardiomyocyte size and diameter, the collagen volume fraction(CVF), perivascular circumferential area (PVCA) and c-fos expression in the left ventricular tissue.RESULTS: Compared with 8-week-old rats, the SBP, LVMI, cardiomyocyte size and diameter, CVF, PCVA, c-fos expression increased markedly in the 18th week of SHRs.The LVH stopped and c-fos expression decreased whereas SBP changed slightly in animals treated with SMB.CONCLUSION: Chronic treatment with SMB can inhibit the development of LVH in SHR, which is probably related to the decease of cardiac c-fos.

Key words: spontaneously hypertensive rats, left ventricular hypertrophy, Salvia miltiorrhiza Bge, c-fos

CLC Number:

R965
R972.44

CHENG Jun-Yan, LU Zhong-Qiu, LI Zhang-Ping, CHEN Shou-Quan, ZHEN Zhi, WANG Qun-Ji. Effects of Salvia miltiorrhiza Bge on left ventricular hypertrophy in spontaneously hypertensive rats and expression of c-fos[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(7): 807-810.

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