Abstract: AIM: To study the pharmacokinetics of tropisetron chlorate capsule in healthy volunteers.METHODS: After the oral administration of 10mg tropisetron chlorate capsule, the blood concentrations of tropisetron chlorate in eighteen male volunteers were measured by HPLC-UV. Concentrations-time profiles were simulated and pharmacokinetic parameters were calculated with 3P97 software.RESULTS: Pharmacokinetic parameters of tropisetron chlorate capsule were obtained as follows: T_max was 2. 33±0. 43 h, C_max was 10. 48±2. 70 μg·L^-1, and AUC_{0-24 h} was 111. 89±39. 86 h·μg·L^-1.CONCLUSION: A single dose administration of 10 mg tropisetron chlorate can distribute and eliminate quickly, which is safety in volunteers.

Key words: tropisetron hydrochlorate, concentrations, pharmacokinetics, HPLC