Abstract: AIM: To explore the intervention of bennazepril in patients with impaired glucose tolerance (IGT).METHODS: Seventy patients with first diagnosed IGT were enrolled in this study. The control group involved 35 patients dealt with diet and exercise, and the trial group involved 35 patients dealt with diet, exercise and bennazepril. The changes of fasting blood glucose (FBG), 2-hour postprandial blood glucose (P2HBG ), systolic blood pressure (SBP), diastolic blood pressure (DBP) and glycosylated hemoglobin (HbA_1c) values were assayed.RESULTS: After the treatment of 12 weeks, the decreased values of fasting blood glucose and diastolic blood pressure were not difference (P >0. 05), but in the trial group, decreased values of 2-hour postprandial blood glucose and glycosylated hemoglobin A_1c decreased (P<0. 05), and systolic blood pressure also decreased (P<0. 01).CONCLUSIONS: Bennazepril can decrease the 2-hour postprandial blood glucose, glycosylated hemoglobin A_1c and systolic blood pressure. It suggests that Bennazepril can improve the metabolic disorder in patients with IGT.

Key words: impaired glucose tolerance, bennazepril, fasting blood glucose, 2 hour postprandial blood glucose, glycosylated hemoglobin A_1c