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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2004, Vol. 9 ›› Issue (9): 1069-1072.

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Dose conversion among different animals and healthy volunteers in pharmacological study

HUANG Ji-Han,HUANG Xiao-Hui, CHEN Zhi-Yang, ZHENG Qing-Shan, SUN Rui-Yuan   

  1. Anhui Provincial Center for Drug Clinical Evaluation, Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui, China
  • Received:2004-08-16 Revised:2004-08-18 Online:2004-09-26 Published:2020-11-23

Abstract: In order to obtain equivalent dose, a dose conversion was important among different animals and healthy volunteers in preclinical pharmacology and I phase clinical trials. Body coefficient and standard weight were introduced into the formula to estimate the equivalent dose in this paper.

Key words: dose conversion, I phase clinical trial, human equivalent dose, healthy volunteers

CLC Number: