Abstract: AIM: To observe the effect of stress and ovariectomy on behavior activity in mice and the prevention and therapy of the TCM complex Ⅰ composed of spine date seed and common anemarrhena rhizome.METHODS: The effect of stress and ovariectomy were investigated on bedtime, survival time under hypoxia, climbing time on the string and number of times of the activity in mice, and the prevention and therapy of TCM the complex Ⅰwere observed.RESULTS: The effect of stress, ovariectomy, stress and ovariectomy were different on bedtime, survival time under hypoxia and climbing time on the string and the number of times of the activity in mice. The effect of stress and ovariectomy on previous parameters was stronger than that of stress or ovariectomy lonely in mice.The stress and ovariectomy resulted in sleep impairment, the decreasing of the survival time under hypoxia and climbing time on the string, and the increasing of the number of times of the activity in mice.CONCLUSION: The TCM complex I can alleviate the high sensitivity to the environment in mice with ovariectomy and stress, which is similar to the mechanism of human climacteric syndrome.

Key words: stress, ovariectomy, activity, climacteric syndrome