Effect of BCEF0083, bioactive compounds from Entomogenous fungi, on AVP content of hypothalamus, pituitary and expression of glucocorticoidreceptor MRNA of hippocampus in chronic unpredictable stress model ofdepression in rats

Abstract

Abstract: AIM: To study the effect of bioactive compounds from Entomogenous ungl(BCEF0083), on AVP content of hypothalamus, piry and expression glucocorticoid receptor (GR) MRNA of hippocampus in chronic unpredictable stress model of depression in rats.METHODS: The depression animal model was induceby chronic unpredictable stress. The effect of BCEF0083 on AVP content in hypothalamus and pituitary was tested by radioimmunoassay. RT-PCR was used to test the expression of GR MRNA in hippocampus.RESULTS: BCEF0083 decreased the AVP content of hypothalamus and pituitary in chronic unpredictable stressed rats, an dincreased the expression of GR MRNA of hippocampus inchronic stressed rats.CONCLUSION: BCEF0083 ex-hibits antidepressant effect by attenuating the stimulatedfunction of hypothalamus-pituitary-adrenal axis in chronicunpredictable stress model of depression in rats.

Key words: chronic stress, entomogenous fungi, AVP, glucocorticoid receptor

CLC Number:

R965.1

KAN Hong-wei, CHENG Yan, ZHOU Lan-lan, MING Liang. Effect of BCEF0083, bioactive compounds from Entomogenous fungi, on AVP content of hypothalamus, pituitary and expression of glucocorticoidreceptor MRNA of hippocampus in chronic unpredictable stress model ofdepression in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(10): 1143-1146.

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Effect of BCEF0083, bioactive compounds from Entomogenous fungi, on AVP content of hypothalamus, pituitary and expression of glucocorticoidreceptor MRNA of hippocampus in chronic unpredictable stress model ofdepression in rats

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