Effect of luteolin on ulcerative colitis in mice

Abstract

Abstract: AIM: To evaluate the effect of luteolin onulcerative colitis in experimental animals.METHODS: The mouse model of acute colitis was induced by instillation of dinitrochlorobenzene (DNCB)/alcohol. Luteolin(1, 10 and 50 mg·kg^-1 were orally administrated tomice for 3 days. Dartheas, colon weight index, macro-scopic damage in the colon were observed and the activityof MPO and the content of PGE, in colon were also examined.RESULTS: The diarrhea and the colon weight in dex were reduced and the macroscopic damage in the inflammatory colon was effectively attenuated by luteolinThe elevated level of MPO and PGE₂ were also significantly decreased.CONCLUSION: Luteolin can effectively inhibit the inflammatory infiltration, bleeding andproliteration in experimental ulcerative colitis.

Key words: luteolin, ulcerative colitis, myeloperox-idase (MPO), prostaglandin E₂(PGE₂)

CLC Number:

R965.1

ZHOU Zhu-cheng, LIU Bao-lin, WU Wei-wei. Effect of luteolin on ulcerative colitis in mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(10): 1152-1155.

References

1 Dong WG, Liu SP. Yu BP, Wu DF, Lo HS, Yu JP. Ameliorative effects of sodiun ferulate on experimental colitis and their mechanisms in rats [J]. World J Gastroenterol. 003 9: 2533-8
2 Masahiro K. Naoki I, Hiroichi N. Effects of luteolin and other flavonoids on Ige-meiated allergic reactions [J]. Planta Med, 2000: 66: 25-9
3 Kimata M, Shichijo M, Miura TInagaki NH.Effects of luteolin, quercetin and baicalein on mmunoglobulin E-mediated mediator release from human cultured mast cellsLJ. Clin Exp Allergy, 2000: 30: 501-8
4 Kim SJ. Park H, Kim HP. Inhibition of nitric oxide productionfrom lipopolysaccharide-treated RAW 264.7 cells by synthetieflavones: structure-activity relationship and action mechanismI[J]. Arch Pharm Res, 2004: 27: 937-43
5 Kim JA, Kim DK, Kang OH, Choi YA. Park H, Choi SC, eral. Inhibitory effect of luteolin on Tnf-alpha-induced IL-8 production in human colon epithelial cells [J]. Int Immuno Pharmacol. 2005: 5: 209-17
6 Hirano T, Higa S. Arimitsu !, Naka T, Shima Y, Ohshima S, et al. Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by actival-ed human basophils [J]. Int Arch Allergy Immunol, 2004; 134:35-40
7 Butzner JD, Parmar R, Bell CJ, Dalal V.Butyrate enema therpy stimulates mucosal repair in experimental colitis in the ratsII. Gut, 1996; 38: 568-73
8 范春雷,李爱平. 马陆的抗炎药理研究初报[J][J].中国现代应用药学,1998; 15: 19 21
9 Morris GP, Beck PL, Herridge MS, Depew WT, SzewczukMR, Wallace JL. Hapten-induced model of chronie inflanuation and ulceration in the rat colon [J]. Gastroenterology, 1989;96: 795-803
10 朱峰,钱家鸣,潘国宗.细胞免疫性实验性结肠炎动物模型的建立和髓过氧化酶及超氧化物歧化酶的检测[J].中国医学科学院学报,1997;20: 271-8
11 Wallace IL, Ie T, Carter L Appleyard CB, Beck PL. Hapten-in-duced chronic colitis in the rat: alternatives to trinitrobenzenesulfonic acid [J]l. J Pharmacol Toxicol Methods, 1995: 33: 237
12 丁桂风.免疫细胞与炎症介质在肠炎发病中的作用[J]. 生理科学进展,2001;32:232-9
13 Patrignani P, Panara MR, Greco A, usco O, Natoli C, laco-belli S, et al. Biochemical and pharmacological characterizationof the eyclooxygenase activity of human blood prostaglandin endoperoxide synthases J J. J Pharmacol Exp Ther, 1994; 271: 1705
14 Warner TD, Giuliano F, Vojnovic I, Bucasa A, Mitchell JA, Vane JR.Nonsteroid drug selectivities for cyclo-ox genase-irather than cyclo-oxygenenase-2 are associated with human gastrointestinal toxicity: a full in itro analysis [J]. Proc Natl Acad Sci USA. 1999: 96: 7563-8

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