Effects of BCPT on blood level of CORT and ACTH and expression of CRH MRNA of hypothalamuc in chronic stress rats

Abstract

Abstract: AIM: To study the effect of bioactive compounds from paecilomyces tenuipes (BCPT) on the blood level of CORT, ACTH and expression of CRH MR-NA of hypothalamus in chronic unpredictable mild stress model (CUMS) of depression in rats.METHODS: The epression animal model was induced by CUMS. The reward reaction was tested by the sweet water consumptionThe effect of BCPT on the blood level of CORT and ACTHwas tested by radioimmunoassay RT-PCR was used totest the expression of CRH MRNA of hypothalamus.RESULTS: BCPT (40,80 mg·kg^-1) improved the reward re-action by increasing sweet water consumption, decreasing the expression of CRH MRNA of hypothalamus and the blood level of CORT and ACTH in chronic stressed ratsobviously.CONCLUSION: BCPT exhibited antidepres-sant-like effeet may in part be associated with regulating the hyperactingunction of hypothalamic-pitultaryadrenal axis (HPAA).

Key words: paecilomyces tenuipes, depression, CORT, ACTH, CRH

CLC Number:

R965.1

ZHENG Li-fang, KAN Hong-wei, YIN Yan-yan, ZHANG Shen-quan, CHEN-BING, MING Liang. Effects of BCPT on blood level of CORT and ACTH and expression of CRH MRNA of hypothalamuc in chronic stress rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(10): 1162-1165.

References

1 郑丽芳,阚红卫,尹艳艳,明亮. BCPT对慢性应激抑郁大鼠下丘脑、垂体AVP含量及下丘脑AVP mRNA表达的影响[J].中国药理学通报,2005;21:1216-9
2 郑丽芳,明亮,阚红卫,尹艳艳.-种拟青霉代谢物提取物对药物诱导的抑郁小鼠的影响[J].安徽医科大学学报,2005;40:421-3
3 晏忠, 罗质璞.抗抑郁药理实验方法[A].见:张均出主编.现代药理实验方法[M].北京:北京医科大学中国协和医科大学联合出版社,1998:1061-2
4 Willner P、Animal model of depression: an overview[J]. Phar-mac'Ther, 1990;45:425-55
5 Willner P. Validity, reliability and utility of the chronic mildstress tmodel of depression;a 10-year review and evaluation[J].Psychopharmacology(Berl), 1997;134:319-29
6 严灿,邓中炎,王剑,陈孝银.调肝方药对束缚应激大鼠神经内分泌免疫功能的调节作用[J].中国病理生理杂志,2000;16:560-2
7 J.萨姆布鲁克,D.W.拉塞尔,著,黄培堂等译.分子克隆实验指南[M].北京:科学出版社,2002:636-44
8 Baigent SM, Lowy PJ. Mma expression profiles for corticotropin releasing facor (CRE), urocortin, CRF receptor and CRF-bining protein in peripheral rat tissues [J]J. J Molecular Endoxcrinoloy, 2000: 25: 43-52
9 Muscat TR, Papp M, Willner P. Reversad of stress-inchuieed anhedonia by the atypical antide pressants, fluoxetine and maprotiline[J]. Psychopharmacology, 1992: 109: 433-8
10 Arborelius L, Owens M, Plotsky PM.The role of corticotrophinreleasing factor in depress and anxiety disorder [J]. J Endocri-nol,l999;160:1-12
11 Thriviraman KV, Nemeroff CB, Plotsky PM. Sensitivity to glucocorticoid-mediated fast-feed back regulation of the hypothalami-ic-pituitary-adrenal axis is dependent upon stressor specifi neurocircuitry [J]. Brain Res, 2000: 870: 87-101
12 Takeda H. Formation mechanism of stress adaption: role of functional couping of glucocorticoids and brain serotonegic nervous system [J]. Nihon Shinkei Seishin Yakurigaku Zasshi, 2000: 20: 83-9

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