Absorption mechanism and absorption site of oxymatrine in rats

Abstract

Abstract: AIM: To study the absorption mechanism and absorption site of oxymatrine in rats.METHOD: The absorption kinetics and absorption site of oxymatrine were investigated using in situ perfusion method in rats.RESULTS: The absorption mechanism of oxymatrine complied with the passive diffusion and first orderkinet-ics.The absorption rate decreased according to the turn of jejunum ,ileum ,duodenum and colon.The absorption rate constantswere 0.237,0.225,0.200 and 0.062h-1 at jejunum ,ileum ,duodenum and colon ,respectively.CONCLUSION: Oxymatrine can be prepared and pro-cessed into sustained-release dosages forms.

Key words: oxymatrine, rats, absorption site, ab-sorption mechanism, passive diffusion

CLC Number:

R965.1文献标识码:A文章编号:1009-2501(2005)12-1330-05

WANG Su-jun, WANG Guang-ji, LI Xiao-tian, YANG Min, RUAN Jin-xiu, ZHANG Zhen-qing. Absorption mechanism and absorption site of oxymatrine in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(12): 1326-1329.

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