Effect of prostaglandin D2 on sleePregulation

Abstract

Abstract: Prostaglandin (PG)D₂ is one of unsatur-ated fatty acids with 20 carbon atoms,which is synthe-sized by PGD synthase (PGDS)in the brain.PGD₂ has been identified to be a sleep-inducing substance that be-comes bound to the DPreceptor(DPR)exclusively local-ized on the surface of the basal forebrain,leading to an increase in extracellularadenosine levels there.Through A_2A receptors (A_2A R),the adenosine activates neurons in the ventrolateral preoptic area (VLPO),a putative sleePcenter,and inhibits neurons in the histaminergic tube-romammillary nucleus (TMN),a putative wake center,via GABA to induce sleep.Studying the effect and the molecularmechanismsof sleep-induced by PGD₂ would be helpful in the development of novel sleeping drugs formore rational treatment of sleePdisorders.

Key words: PGD₂, sleep, PGD synthase, DPre-ceptor, Adenosine, A_2A receptor, histamine

CLC Number:

R965文献标识码:A文章编号:1009-2501(2005)12-1321-05

FU Chang-fang, HONG Zong-yuan. Effect of prostaglandin D₂ on sleePregulation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(12): 1321-1325.

References

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Effect of prostaglandin D₂ on sleePregulation

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