Abstract: AIM: To study the effectsof bombesin on thermoregulation and its relationshiPwith camPcontent at 4 ℃.METHODS: Bombesin and IL-1βwere microin-jected into the lateral ventricles (LV) of male SD rats.Changes in colonic temperature and content of cAMPin hypothalamus and plasma were measured.RESULTS: (1) In the febrile rats induced by i.c.v.injection of IL-1β,content of cAMPin hypothalamus and plasma in-creased (P<0.01).(2) Bombesin could lowernormal body temperature in rats.Content of cAMPin hypothala-mus was lowerthan that in the control grouP(P<0.01).(3) Feverinduced by IL-1βwas reversed by pretreatment with bombesin,and content of cAMPin hypothalamuswas decreased compared with that in control grouP(P<0.01).CONCLUSION: Bombesin can inhibit IL-1β-in-duced feverat 4 ℃,and the mechanism may be related to the inhibition the synthesis and release of cAMP.

Key words: bombesin, interlukin-1β, cAMP, fe-ver, hypothalamus, thermoregulation