Abstract: AIM: To explore the difference of efficacy and safety between combination of growth hormone and somatostain and single somatostain in treatment of patients with severe acute pancreatitis.METHODS: The case fatality rates and complication incidence of patients with severe acute pancreatitis were analyzed by Meta-analysis in homogeneity test and combined test in 6 studies.RESULTS: Homogeneity test showed that the cited studies of case fatality rates and complication incidence were homogeneous withχ² =3.156,χ² =1.210,P>0.05.In combined test,the combined Or=3.164,Or=3.209 and its 95 % confidence interval was in 1.390 ~ 7.200 and 1.747 ~ 5.900,respectively.CONCLUSION: The case fatality rates in combination grouPwere significantly lowerthan those in single somatostain group.The efficacy of combination grouPwas superiorto that of single somatostain group.

Key words: Meta-analysis, growth hormone, somatostain, pancreatitis, recombination, fatality rate, complication