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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2005, Vol. 10 ›› Issue (5): 485-488.

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Oxidative stress and Alzheimer's disease

HUANG Yan, DONG Zhi   

  1. Department of Pharmacology, Chongqing Medical University, Chongqing400016, China
  • Received:2005-03-04 Revised:2005-04-19 Online:2005-05-26 Published:2020-11-19

Abstract: Alzheimer's disease (AD)is a kind of neuro-degenerative disease mainly affecting both cognition and behavior, and pathologically characterized by deposi-tion of amyloid-beta peptides as senile plaques and by the occurrence of neurofibrillary tangles (NFT).AD is corre-lated with many factors, there are several hypotheses about AD, and one of them is oxidative stress and some anti-oxidative drugs demonstrated effective. This paper reviewed the relation between oxidative stress and AD, and the recent study on anti-oxidative drugs for AD.

Key words: oxidative stress, Alzheimer's disease, free radical, anti-oxidative drugs

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