Abstract: AIM: To evaluate the effects of different formulations of cyclosporine A on trough blood concentration in patients with myasthenia gravis.METHODS: Retrospectively analyzed the medical documents and information on medications and drug monitoring data of 189 myasthenia gravis patients admitted during the period of the transversion of cyclosporine A formulation.RESULTS: The trough blood concentration of cyclosporine A increased with the increase of medication dosage, and the microemulsified formulation was related to the last dose of cyclosporine A while the oil-based formulation was related to the last day dosage of cyclosporine A.No statistical difference of trough blood concentration was observed between the two formulations, weight was little meaningful for the calculation of cyclosporine A dosage, especially in the case of microemulsified form.CONCLUSION: The conversion from oil-based formulation to microemulsified formulation is the clinical trend, but it is very important to utilize the newer one in the efficient and reasonable way for the treatment of myasthenia gravis.

Key words: cyclosporine A, myasthenia gravis, blood trough concentration, microemulsified formulation, oil-based formulation