Abstract: AIM: To study effects of dammonii glycyrrhizinatis (DG) on lipid peroxidation and enzyme activity in the ischemia-reperfusion myocardium rats. METHODS:30 male Wistar rats were divided into 3 groups:sham group, ischemia-reperfusion group and DG group (20 mg·kg^-1) (n = 10).Myocardial ischemia reperfusion injury model was produced by the 30 min ligation of left descending coronary artery (LAD) and 60 min reperfusion in rats.The content of myocardial malondialdehyde (MDA), the activities of myocardial superoxide dismutase (SOD), adenosinetriphosphatase (ATPase) and plasma lactate dehydrogenase (LDH), creative phosphokinase (CPK) level were measured by colorimetry, and the activities of succinate dehydrogenase (SDH) were measured by histochemical stain after reperfusion.RESULTS: DG significantly reduced myocardium MDA content (P <0.05 or P <0.01), enhanced the activities of SOD, ATPase and SDH (P <0.05, P <0.01) and decreasedmyocardial LDH and CK release (P <0.05 or P <0.01).CONCLUSION: DG can protect myocardium against ischemia-reperfusion injury, and its mechanism may be related to the reduction of myocardial lipid peroxidation, the enhancement of SOD, SDH and ATPase activities.

Key words: diammonii glycyrrizinatis, myocardial reperfusion injury, superoxide dimutase, adenosinetriphosphatase, succinate dehydrogenase