Effects of Astragalus polysaccharide and total glucosides of paeony on synergistic antiplatelet aggregation in rabbits

Abstract

Abstract: AIM: To study the interaction effects of Astragalus polysaccharide (APS) and total glucosides of paeony(TGP) with various dosage on the platelet aggregation.METHODS: Platelet aggregation was estimated by the turbidimetric method.The best interaction effects were determined by uniform design method.RESULTS: APS showed apparent anti-platelet effects and better combination with TGP, and the ratio of 12 ∶1 was the best one.CONCLUSION: APS concerted with TGP inhibits platelet aggregation.

Key words: Astragalus polysaccharide, total glucosides of paeony, platelet aggregation, uniform design, synergistic action

CLC Number:

R972.4

WEI Yi, LIU Ting-ting, LIN Ting-ting, LIU Yu-yin, SU Xiao-ming. Effects of Astragalus polysaccharide and total glucosides of paeony on synergistic antiplatelet aggregation in rabbits[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(8): 932-934.

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Effects of Astragalus polysaccharide and total glucosides of paeony on synergistic antiplatelet aggregation in rabbits

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