Abstract: AIM: To investigate the antioxidative effect of in Alzheimer's Disease mice.METHODS: AD model mice were made by D-galactose and aluminum chloride, and administered with the soybean isoflavone active-extracts for 15 days.The activities of SOD and LDH, and the levels of MAD were measured in serum. The morphology and quantity of nerve cells were observed in hippocampus tissue.RESULTS: The activities of SOD and LDH significantly increased in the ISO groups(P < 0.01), the MAD levels obviously decreased in the model group(P <0.01), the quantity of the nerve cells increased, and its morphology was better than that in the model group.CONCLUSION: The soybean isoflavone active-extracts can improve the antioxidative functions in AD mouses.

Key words: soybean isoflavone active-extracts, AD mice, antioxidative, hippocampus, nerve cells