Welcome to Chinese Journal of Clinical Pharmacology and Therapeutics,Today is Chinese

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2006, Vol. 11 ›› Issue (1): 74-77.

Previous Articles     Next Articles

Meta-analysis of effectiveness of fluoxetine in treatment of post-stroke de- pression

JIANG Ya-bin   

  1. Department of Emergency , First Affiliated Hospital of J inan University, Guangzhou 510632 , Guangdong, China
  • Received:2005-08-22 Revised:2005-10-27 Online:2006-01-06 Published:2020-10-23

Abstract: AIM :To further investigate the effective- ness and safety of fluoxetine in treatment of post-stroke depression ( PSD) .METHODS :The effectiveness and safety of fluoxetine in treatment of PSD patients in 13 con- trolled studies were analyzed by meta-analysis again in or- der to assess the comprehensively significant differences and effect size ( ES ) .RESULTS:( 1) The scores of Hamilton, and degrees of neurological functional defect and Barthel index in PSD patients before and after treat- ment with fluoxetine had significant difference ( P < 0 .0005) , and ES :dmean >0 .8 .( 2) Improving degrees of depression symptom, neurological functional defect and activity of daily living scale ( ADL) between fluoxetine treatment group and control group had significant differ- ence ( P <0 .0005) , and ES :dmean >0 .8 .CONCLU- SION:Fluoxetine can significantly ameliorate the depres- sion symptom, neurological functional defect and ADL of patients with PSD, and it has few side effects .

Key words: stroke , depression , fluoxetine, neuro- logical function , Meta-analysis

CLC Number: