Abstract: This issue introduces the existing problems and corresponding countermeasure about the compensation to the subjects'impairment in Chinese clinical drug trial nowadays.It suggests that the corresponding laws of impairment compensation should be perfected.Moreover,during the designation, the inspection of ethics inspection committee, the execution of informed consent and the compensation problem must be clarified.It also appeals the establishment of compensation fund and related accidence insurance, from which the compensation shall be made after the analysis and assessment of professional institute,thus the clinical drug trials can be guaranteed successfully.

Key words: clinical trial, impairment compensation, good clinical practice