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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2006, Vol. 11 ›› Issue (5): 481-484.

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Review on endothelial dysfunction in atherosclerosis and drug therapy

HU Zhe-yi, WANG Qiu-juan, DING Xuan-sheng1   

  1. Department of Physiology, 1Research Division of Pharmacology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China
  • Received:2006-03-06 Revised:2006-04-10 Online:2006-05-26 Published:2020-12-09

Abstract: Endothelial dysfunction plays a crucial role in the development of arteriosclerosis (AS).Accu-mulating evidence suggests that endothelial dysfunction is an initiating event in the etiology of arteriosclerosis.This article reviewed the relationship between endothelial dys-function and atherosclerosis, and the effects of therapeutic drugs especially statins on endothelial dysfunction.

Key words: atherosclerosis, endothelial dysfunc-tion, drug therapy

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