A cical study on codirtiono of Cyloporin A and beberin hydro-chlride in renal transplanted recipients

Abstract

Abstract: AIM: To study the eflect of berberinhydrochloride (Ber) on the elevation of blod concentra-tion of Cyelosporin A (CsA) and liver and renal functionsin renal transplanted recipients. METHODS: 138 caseswith renal transplantation in experimental group weretreated with CsA and Ber and 150 cases with renal trans-plantation in control group received CsA only. Blood lev-els of CsA, biochemistry indexes for liver and renal func-tion were detennined. RESULTS: After 1,3,6 monthscombined with Ber, blood concentrations of CsA in pa-tients went up by 49.8%,81 4%.36.9% and the radiosof blood concentration of CsA to CsA dosage inereased taking Ber(P < 0.01). ht had a sigifiant increase com-pared with the control group(P < 0.01). No significantffet on liver or renal function was obsenved when com-bined with Ber and CsA. CONCLUSION: Ber couldmarkedly elevale the blood concentration of CsA in renaltransplanted recipients and did not inerease the toxicity ofCsA. Ber combined with CsA can be used as a method forsaving money on CsA.

Key words: renal transplantation, Cyclosporin A, berberin hydnchloride, drug concentration in blod, clini-cal study

CLC Number:

R969

YU Ai-rong, XIN Hua-wen, WU Xiao-chun. Li Qing. A cical study on codirtiono of Cyloporin A and beberin hydro-chlride in renal transplanted recipients[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(12): 1415-1418.

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