Relationship between type 2 diabetes and leptin resistance and its gene polymorphisms

Abstract

Abstract: Leptin has many important pathophysiological effects, such as inhibiting insulin secretion and expression, constraining pancreatic β cell apoptosis and controlling glucose metabolism through skeletal muscle cell and hepatic cell.This review summarizes the phenomena of leptin resistance and leptin gene polymorphism in vivo, particularly emphasizing its correlation with type 2 diabetes and drugs clinical effective.

Key words: leptin, leptin resistance, gene polymorphism, type 2 diabetes

CLC Number:

R587.1

LIU Hai-ling, TAN Yuan-ming, LIU Zhao-qian. Relationship between type 2 diabetes and leptin resistance and its gene polymorphisms[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(3): 262-265.

References

1 Vettor R, Milan G, Rossaton M, et al.Review article:adipocytokines and insulin resistance[J].Aliment Pharmacol Ther, 2005;22:3-10.
2 陈晓燕, 常志文.可溶性瘦素受体的研究进展[J].临床荟萃, 2004;19:408-410.
3 Seufert J, Kieffer TJ, Leech CA, et al.Leptin suppression of insulin secretion and gene expression in human pancreatic islets: Implications for the development of adipogenic diabetes mellitus [J].J Clin Endocrinol Metab, 1999;84:670-676.
4 Yildiz BO, Haznedaroglu IC.Rethinking leptin and insulin action: Therapeutic opportunities for diabetes[J].Int J Biochem Cell Biol, 2006;38:820-830.
5 Zhao YF, Feng DD, Chen C.Contribution of adipocyte-derived factors to beta-cell dysfunction in diabetes[J].Int J Biochem Cell Biol, 2006;38:804-819.
6 Leclerc I, Woltersdorf WW, da SilvaXavier G, et al.Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets:Impact on glucose-stimulated insulin secretion [J].Am J Physiol Endocrinol, 2004;286:1023-1031.
7 McMinn JE, Seeley RJ, Wilkinson CW.NPY-induced overfeeding suppresses hypothalamic NPY mRNA expression:potential roles of plasma insulin and leptin[J].Regul Pept, 1998;25:425-431.
8 Toyoshima Y, Gavrilova O, Yakar S, et al.Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes[J].Endocrinology, 2005;146:4024-4035.
9 Ceddia RB.Direct metabolic regulation in skeletal muscle and fat tissue by leptin:implications for glucose and fatty acids homeostasis[J].Int J Obes, 2005;29:1175-1183.
10 Bastard JP, Maachi M, Lagathu C, et al.Recent advances in the relationship between obesity, inflammation, and insulin resistance[J].Eur Cytokine Netw, 2006;17:4-12.
11 Dulloo AG, Stock MJ, Solinas G, et al.Leptin directly stimulates thermogenesis in skeletal muscle[J].FEBS Lett, 2002; 515:109-113.
12 刘新颜, 王建军.瘦素与胰岛素[J].川北医学院学报, 2005;20:232-235.
13 王晓珊, 樊均明.瘦素与糖尿病研究进展[J].华西医学, 2004;19:697-698.
14 Van der Lende T, Te Pas MFW, Veerkamp RF, et al.Leptin gene polymorphisms and their phenotypic associations[J].Vitam Horm, 2005;71:373-405.
15 Ren W, Zhang SH, Wu J, et al.Polymorphism of the leptin gene promoter in pedigrees of type 2 diabetes mellitus in Chongqing, China[J].Chin Med J, 2004;117:558-561.

[1]	MA Yan, TIAN Gaopeng, SHI Xingwen, SUN Ting, XIE Jingjing, ZHEN Donghu. Correlation between 25(OH)D and metabolically related fatty liver in T2DM population [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(9): 1018-1026.
[2]	MA Xiankang, YANG Lixia, CUI Yangyang, MI Denghai. Angelica polysaccharides improve hepatic endoplasmic reticulum stress by inhibiting the expression of GRP78, p-PERK and p-Eif2α in diabetic KK-Ay mice [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(8): 926-936.
[3]	LI Qinghua, ZHAO Yan, ZHAO Haigang, GAO Pengfei, XU Bingxin. Value of ABCB1 G2677T gene polymorphism detection in lipid-lowering therapy with atorvastatin in patients suffered from ischemic stroke [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(6): 633-640.
[4]	ZHU Li, WEI Bing, LIAO Shi'e, ZHANG Chao, ZHENG Xiaoyu, LIU Yajun. Effects of single nucleotide polymorphism of drug metabolizing enzyme cytochrome P450 on the efficacy of inhaled cortisol hormone in asthmatic children [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(5): 536-543.
[5]	HOU Ruiying, GUO Lige, JIAO Weijie, DU Lei, WU Guiyue, ZHAO Xu. Effects of Xiaokeshu recipe on levels of serum inflammatory factors in type2 diabetic rats and its mechanism [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(4): 377-382.
[6]	ZHANG Zhiying, JIN Xiuhong, ZHANG Xiaoning, ZHANG Xiangfeng, LUO Qinglin, ZHANG Songlin. Clinical study of TBX21 and ADCY9 polymorphisms in the develop- ment of childhood asthma [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(4): 407-412.
[7]	ZHAO Shifeng, SONG Xiangming, YAO Jianping. Tirzepatide: A new glucagon-like peptide-1 receptor/glucose-dependent insulinotropic peptide receptor dual agonist [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(2): 220-227.
[8]	DU Xiaoyu, LI Yumeng, WU Huizhen, QIU Bo. Pharmacological and clinical evaluation of Dorzagliatin in the treatment of type 2 diabetes [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(10): 1177-1183.
[9]	CAI Jing, PAN Binjing, LIU Jingfang. Research progress on the relationship between hypoglycemic drugs and sarcopenia [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(1): 101-108.
[10]	ZHAI Weiwei, YU Qiaoling, LIU Ping, QIU Bo, WU Huizhen. Research progress of finerenone in the treatment of type 2 diabetes mellitus complicated with chronic kidney disease [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(9): 1067-1074.
[11]	FU Hong, TIAN Lei. Individualized precision therapy for patients with ischemic stroke and hypertension [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(8): 870-876.
[12]	CHEN Wengang, YIN Qin, ZHANG Weiwei, ZHOU Lulu, KOU Wanqing, YUAN Xiaolong. Distributions of MTHFR gene polymorphism and its correlation with blood Hcy in patients with hypertension in southern Anhui province [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(7): 768-774.
[13]	LU Senlin, LIU Xinyuan, WANG Jili, HUANG Xiaofei. Research progress of virus-mediated gene therapy in type 2 diabetes mellitu [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(7): 800-807.
[14]	WU Yuanzhu, LIU Jun, YANG Kui, PENG Jing, LUAN Jiajie, WEI Jun, ZHANG Dafa, SONG Shuai, YUAN Xiaolong, WANG Zhongfang, ZHANG Nianbao, XIE Dan, JIANG Peng, FAN Jie. Distribution of CYP2C9*3 and VKORC1-1639G>A gene polymorphism in Anhui Han population and their influence on the stable dose of warfarin [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(6): 652-659.
[15]	ZENG Xiaofan, XU Yiqi, LIU Shu, WU Qian, LI Zibao, HE Junjun, JIN Yuelong, ZHAO Yongli, HE Chunling, GAO Jialin. Retrospectively analysis of the effect of low-dose aspirin on primary prevention of non-fatal myocardial infarction and cerebral infarction in patients with type 2 diabetes mellitus [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(6): 665-671.