Abstract: AIM: To compare the T/P ratio and the smoothness index of blood pressure in the treatment of mild to moderate essential hypertension with fixed-dose valsartan/hydrochlorothiazide (80/12.5 mg) and valsartan (80 mg) , and to evaluate the depressurization therapeutic effect of valsartan/hydrochlorothiazide (80/12.5 mg) .METHODS: 84 patients with mild to moderate essential hypertension(SBP≥140 mm Hg and <160 mm Hg, DBP ≥95 mm Hg and <110 mm Hg) had been divided into randomly valsartan hydrochlorothiazide group and valsartan group.The treatment lasted for 8 weeks and the changes of blood pressure and biochemical indicator were observed be-fore and after treatment .RESULTS: The effective rate of depressurization in valsartan/hydrochlorothiazide group and valsartan group were 84.2% , 52.5% re-spectively .The rate of patient reaching goal BP levels were 73.9%, 42.9%respectively .There was statisti-cally significant difference between the two groups(P < 0.001) .The T/P ratio of SBP was 76.7%, the DBP was 71.2%in valsartan/hydrochlorothiazide group, the smoothness index of SBP was 1.14 ±0 .39, the DBP was 1.09±0 .27.The T/P ratio of SBP was 77.6%, the DBP was 71.3%, The smoothness index of SBP was 1.24 ±0.39, the DBP was 1.19 ±0.27.There were no significant difference (P>0.05) between the T/P ratio and smoothness index in the both groups. CONCLUSION: The efficacy of fixed-dose Valsartan Hydrochlorothiazide (80/12.5 mg) was superior to val-sartan(80 mg) monotherapy in the treatment of mild to moderate essential hypertension.

Key words: valsartan/hydrochlorothiazide, valsar-tan, essential hypertension, smoothness index, T/Pratio