Abstract: AIM: To compare the efficacy and safety of oxiracetam and donepezil in treating Alzheimer disease with mild and moderate MMSE scores. METHODS: 68 patients were randomly divided into oxiracetam group(p.o., n =34) and donepezil group (p.o., n =34). The MMSE and Blessed-Roth measuring scales were used to evaluate the curative effects before treatment and three months after treatment. RESULTS: There were significant differences between the indexes expect for activities of daily living before and after treatment in two groups (P <0.01). The isoeffect or unpessimum test showed the MMSE scores in the two groups were isoeffective, the Blessed-Roth scores in oxiracetam group were inferior to those in donepezil group(P >0.05). CONCLUSION: The curative effect and safety of oxiracetam and donepezil in treating mild and moderate Alzheimer disease are similar.

Key words: oxiracetam, donepezil, Alzheimer disease