Pufferfish type Ⅰ collagen extract prevented and cured myelosuppression induced by cyclophosphamide or diamminedichloroplatinum or cytosine arabinoside in mice

Abstract

Abstract: AIM:To observe the effects of Pufferfish type Ⅰ collagen extract (PTICE) on mouse toxic and adverse reactions induced by cyclophosphamide (CTX) or diamminedichloroplatinum (DDP) or cytosine arabinoside (Ara-c). METHODS:Mouse myelosuppression model was induced by i. p. CTX or DDP or Ara-c, i. g. PTICE to prevent and cure. The mental status, level of body weight and pelage were observed. The peripheral hemogram, spleen index, and contents of bone marrow DNA were determined. RESULTS:PTICE could obviously improve the mental status, protect the pelage, raise the counts of white blood cell, platelet, neutrophil, lymphocyte and increase the spleen index and contents of bone marrow DNA. PTICE decreased the mice mortality rate induced by DDP. CONCLUSION:PTICE could reduce myelosuppression induced by cyclophosphamide or diamminedichloroplatinum or cytosine arabinoside in mice.

Key words: Pufferfish type Ⅰ collagen extract, cyclophosphamide, diamminedichloroplatinum, cytosine arabinoside, myelosuppression

CLC Number:

R965.2

LI Sheng-qian, CHEN Ding-ding, GAO Li-zhong. Pufferfish type Ⅰ collagen extract prevented and cured myelosuppression induced by cyclophosphamide or diamminedichloroplatinum or cytosine arabinoside in mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(2): 201-207.

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