Research progress on gene variants of the ABCC family

Abstract

Abstract: The ABCC (ATP-Binding Cassette, Subfamily C, ABCC) family is a large protein family discovered recently. It is comprised of nine members which distribute widely in human body and participate in the transportion of many important substrates. Some chemotherapeutic agents are also substrates of ABCC whose over-expressions have been proved to be associated with multidrug resistance. Recently, some studies showed that some mutations of ABCC family could affect the substance metabolism and lead to tumor multidrug resistance, even result in genetic disorders. The genetic variants of the ABCC family and their association with tumor multidrug resistance were reviewed in this paper.

Key words: ABCC family, genovariation, multidrug resistance, polymorphism

CLC Number:

R730

YIN Ji-ye, LIU Zhao-qian. Research progress on gene variants of the ABCC family[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(2): 220-227.

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