Relationship between type 2 diabetes and retinol binding protein 4 and its genetic poly morphism

Abstract

Abstract: Retinol-binding potein ( RBP) is the primary transport protein for retionl. Serum plasma levels of RBP can serve as an index for detecting the development and the curative effects of the diseases of kindey and liver, as well as nutnitional diseases. Recent research reported that retinol binding protein 4(RBP4) is a newly discovered messenger fiom adipocyte, which plays a role in insulin resistance and obesity. The research and findings of the structure, gene polymorphism of RBP4, and association of RBP4 with type 2 diabetes ( T2DM) was reviewed in this article.

Key words: retinol binding protein 4, single nucleotide polymorphism, type 2 diabetes

CLC Number:

R589

ZHOU Fang, ZHOU Hong-hao, LIU Zhao-qian. Relationship between type 2 diabetes and retinol binding protein 4 and its genetic poly morphism[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(4): 452-456.

References

[1] Blomhff R,Green MH,Berg T,et al. Transport and storage of vitamin A[J. Sdience,1990,250(4979):399-404.
[2] Aeberli I,Biebinger R,Lehmann R,et al. Seum retinolbinding protein 4 concentration and its ratio to serm retinol are associated with obesity and metabolic syndrome components in children[J]. J Clin Endoci nol Metab,2007,92(11):4359-4365.
[3] Isozaki M,Masubuchi Y,Horie T. Evaluation of drug; induced hepatotoxicity by plasma retiml binding protein[J].In lio,2002,16(1):61-65.
[4] 乔玉峰,庞东梓.糖尿病肾病早期诊断指标研究进展[J].国外医学泌尿系统分册,2005,25(5):670-672.
[5] Yang Q,Graham TE,Mody N,et al. Senum ret inol binding protein 4 contributes to insulin resistance in obesity and type2 diabetes[J].Nature,2005,436(7049):356-362.
[6] Graham TE,Yang Q,Bliher M,et al. Retinok binding protein 4 and insulin resistance in lean,obese,and diabetic subjet[J]. N Engl J Med,2006,354(24):2552-2563.
[7] 陈健,周度金.视黄醇类结合蛋白的分类结构及功能[J].生命的化学,2004,24(2):112-115.
[8] Naylor HM,Newcomer ME. The structure of human retinol-bingding protein whit its carrier protein transt hy retin reveals an intenaction with the carboxy teminus of RBP[J].Biochemistry,1999,38(9):2647-2653.
[9] 陈健,陈敏,陈彬,等.视黄醇结合蛋白RBP4可与多种核受体相互作用[J].中国生物化学与分子生物学报,2004,20(5):696-701.
[10] 梁学颖,徐琪寿.视黄醇结合蛋白的分子生物学[J].生理科学进展,2000,31(3):277-279.
[11] Munkhtulga L,Nakay ama K,Utsumi N,et al. Identification of a regulatory SNP in the retinol binding protein 4gene associated with type 2 diabetes in Mongolia[J]. Hum Genet,2007,120(6):879-888.
[12] Craig RL,Chu WS,ElbeinSC. Retinol bindi ng protein 4 as a candidate gene for type 2 diabetes and prediabetic intemediate traits[J]. Mol Genet Metab,2007,90(3):338.
[13] 吴海娅,贾伟平,魏丽,等.肥胖及2型糖尿病患者血清视黄醇结合蛋白4水平的变化及其临床意义[J].中华内分泌代谢杂志,2006,22(30):290-293.
[14] Graham TE,Yang Q,Bliher M,et al. Reti nok Binding Prtein 4 and Insulin Resistance in Lean,Obese,and Diabetic Subjects[J]。N Engl J Med,2006,354(24):2552-2563.
[15] Khting N,Graham TE,Bemdt J,et al. Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra abdominal fat mass[J]. Cell Metab,2007,6(1):79-87.
[16] Stefan N,Hennige AM,Staiger H,et al. High circulating ret inot binding protein 4 is associated with elevated liver fat but not w ith total,subcutaneous,visceral,or intramyo cellularfat in humans[J].Diabetes Care,2007,30(5):1173-1178.
[17] Cho YM,Youn BS,Lee H,et al. Plama retinol binding protein4 concent rations are elevated in human sub jects with impaired glucose tolerance and type 2 diabetes[J].Diabetes Care,2006,29(11):2457-2461.
[18] Jia W,WuH,Bao Y,et al. Association of serum retinol-binding protein 4 and visceral adi posity in Ch inese sub jects with and without type 2 diabetes[J].J Clin Endocrinol Metab,2007,92(8):3224-3229.
[19] Yao Borengasser A,Vamma V,Bodles AM,et al. Retinol bindi ng protein 4 expression in humans:relationship to in sulin resistance,inf lammation,and lesponse to pioglita zone[J]. J Clin Endocrinol Metab,2007,92(7):2590-2597.
[20] Munkhtulga L,Nakayama K,Utsumi N,et al. Identification of a regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia[J]. Hum Genet,2007,120(6):879-888.
[21] Craig RL,Chu WS,Elbein SC. Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intemediate traits[J].Mol Genet Metab,2007,90(3):338-344.
[22] Hu C,Jia W,Zhang R,et al. Efect of RBP4 gene variants on circulating RBP4 concentration and Type 2 diabetes in a Chinese population[J].Diabet Med,2008,25(1):11-18.