Abstract: AIM: To study the mechanism of Huoxuetongqiao patch in transdermal delivery andmagnetic field on experimental cerebral hemorrhage rabbits.METHODS: The cerebral hemorhage model rabbits were randomly divided into four groups: normal control group, model group, herbs group and herbs in magnetic field group.The normal control group and the model group were not treated.The herbs group were given Huoxuetongqiao herbs.Herbs in magnetic field group were given Huoxuetongqiao patch in the magnetic field.Hemorheology indices and SOD and MDA were detected respectively.RESULTS: Most of the hemorheology indices significantly decreased compared with those in normal control group.And one hour later, the main indices of hemorheology indices decreased below the normal level.In addition, the content of SOD obviously decreased and the content of MDA inmodel croup increased compared with those of normal control group (P<0.01).Compared with model group, the content of SOD increased and the content of MDA was obviously decreased in herbs group and herbs in magnetic field group (P<0.01 or P<0.05).Otherwise, those of herbs in magnetic field group were more significant compared with herbs group.CONCLUSION: Huoxuetongqiao patch can obviously improve the hemorheology of rabbits with cerebral hemorrhage, increase the content of SOD and induce the content of MDA.These may be the partial mechanisms of patch on experiment cerebral hemorrhage rabbits.

Key words: Huoxuetongqiao patch, cerebral hemorrhage, hemorheology, SOD, MDA