Advancement of research on the role and signal transduction pathway of gastrin in gastroenteric tumor

Abstract

Abstract: Studies have proved that gastrin plays key roles in the development and progression of gastroenteric tumor.After gastrin combined with the tumor cell surface receptors, some genetic transcription and expression were adjusted through certain signal transduction pathways, resulting in the development and growth of gastrointestinal carcinoma.Effective treatment method would been founded about gastroenteric tumor through the studies of mechanism of action and signal transduction pathways of gastrin in gastroenteric tumor.

Key words: gastrin, receptor, signal transduction, focal adhesion kinase (FAK)

CLC Number:

R735

PAN Jun-tao, WU Pei. Advancement of research on the role and signal transduction pathway of gastrin in gastroenteric tumor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(7): 822-827.

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