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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2008, Vol. 13 ›› Issue (8): 852-855.

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Study on effects of hirsutella sinensis fermented mycelia on immunologic function in mice

GE Fei1,2, Gui Lin3, LI Wan-zhen2, FAN Mei-zhen1   

  1. 1AnhuiProvincial Key Laboratory of Microbial Pest Control, AnhuiAgricultural University, Hefei 230036, Anhui, China;
    2Department of Biochemical Engineering, AnhuiUniversity of Science and Technology, Wuhu 241000, Anhui, China;
    3Department of Microbiology and Immunology, WannanMedical College, Wuhu 241001, Anhui, China
  • Received:2008-06-30 Revised:2008-07-24 Online:2008-08-26 Published:2020-10-12

Abstract: AIM:To investigate the effects of hirsutella sinensis fermented mycelia on immunologic function in mice.METHODS:The mice were reared with hirsutella sinensis fermented mycelia at the doses of 50, 200 and 800 mg/kg for 5 days for tests of carbon clearance, serum haemolysin and delayed-type hypersensitivity (DTH)induced by 2-dinitro fluoro benzene (DNFB).RESULTS:The medium and high doses of 200 and 800 mg/kg enhanced phagocytosis by uninucleate macrophages, humoral immunity and cellular immunity of mice significantly with obvious dose dependence.CONCLUSION:These results suggest that the hirsutella sinensis fermented mycelia has substantial immunoregulation function.

Key words: hirsutella sinensis, mycelia, immunoregulation

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